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The concept of non conjugated bilirubin as a powerful antioxidant could be the answer, from a teleological point of view, to mammals necessities for producing bilirubin and not stopping the catabolic chain from heme to biliverdin (BV) like amphibian, reptiles and birds do (10)

Nearly all animal research uses either intraperitoneal (into the abdominal cavity), intramuscular, or subcutaneous injection

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[DOI] [PubMed] [Google Scholar] 206.Andino D., Moy J., Gaynes B.I

[DOI] [PubMed] [Google Scholar] 36.Silverman J.L., Yang M., Lord C., Crawley J.N